If there is one thing that undermines Darwinian evolution, that is, the insistence that random mutations and natural selection are the singular keys to the origins of life and species, it would be the cell’s ability to “think,” make decisions, and alter its DNA accordingly. This idea is implied in the works of Jean-Baptiste Lamarck (1809) and it resurfaced as “directed mutation” by Cairns et al. (1988). The cell’s active participation (instead of a passive recipient) in its evolutionary direction is unthinkable for many researchers mainly because it undermines randomness and natural selection and extends change potential to the cell itself. How much of biological evolution is random and how much is directed or purposefully initiated by the cell? How does this relate to consciousness and the cell’s ability to “think,” make decisions, and alter its DNA? These are issues the academic community must take seriously.